adjust volume by intracranial volume (ICV)

icv_adjust(volume, icv)

Arguments

volume

volume

icv

intracranial volume

Value

volume_adj volume adjusted for ICV

Details

  1. GLM of volume as the DV and mean-centered ICV as the IV
    \(volume_i = b_0 + b_1 * icv_{mc_i}\) (Eq. 1)

  2. Adjust volume by subtracting the original volume by the product of the slope (\(b_1\)) from equation 1 and mean-centered ICV
    \(volume_{adj_i} = volume_i - (b_1 * icv_{mc_i})\) (Eq. 2)

References

Raz N, Rodrigue KM, Kennedy KM, Head D, Gunning-Dixon F, Acker JD. Differential aging of the human striatum: longitudinal evidence. AJNR Am J Neuroradiol. 2003 Oct;24(9):1849-56. PMID: 14561615; PMCID: PMC7976312.